A brilliantly-worked goal by Ryan Christie and a Justin Kluivert penalty gave Bournemouth shock 2-0 Premier League win at home to 10-man Arsenal.
Manchester City have one just victory from their last 10 games across all competitions.
Arsenal ended Leicester City's brief stay at the top of the Premier League on Sunday despite being held to a 0-0 draw at Stoke City after Manchester United's Wayne Rooney struck late for a 1-0 win at Liverpool.
An opening-day Premier League defeat, a growing injury list and the weight of an unspent transfer kitty hang heavily over Arsenal as they head into Wednesday's Champions League playoff clash with Fenerbahce.
Roberto Firmino's 90th-minute header sent Liverpool back to the top of the Premier League with a 2-1 victory over Tottenham Hotspur, whose 11-match unbeaten run came to an end on Wednesday.
As Chelsea and Manchester United undergo a Premier League title-tussle, a different battle emerges this Sunday when Arsenal visit a Liverpool side aiming to protect their 'big four' status.
Arsenal returned to the top of the Premier League with a comfortable 2-0 victory over relegation-threatened Luton Town
Arsenal eased past second-tier Reading 2-0 with Alex Oxlade-Chamberlain scoring twice, while Newcastle United romped to a 6-0 win over 10-man Preston North End and Hull City won 2-1 at Bristol City.
Arsenal took the race to the final day last season and are strongly tipped to end Manchester City's dominance this time.
Real Madrid fought back from two goals down as Vinicius Jr grabbed a hat-trick in a thrilling 5-2 win over visitors Borussia Dortmund in the Champions League.
Barcelona made a disappointing start to their Champions League campaign by losing 2-1 to AS Monaco on Thursday.
Arsenal, long accused of being too weak during an eight year spell without a trophy, showed their growing resilience in Sunday's narrow win at Newcastle United that sent them back to the top of the table, manager Arsene Wenger said.
Chelsea's Didier Drogba proved Arsenal's nemesis again as he inspired the champions to a 2-0 win over their London rivals and Blackpool pulled off a stunning 2-1 victory at Liverpool in the Premier League on Sunday.
'The boys will be pleased not to lose but also definitely not happy we didn't win.'
With the Champions League final kicking off on Saturday evening, authorities are bracing for both sets of spectators to spill out onto the streets of western Paris around the same time.
Liverpool owner John W Henry appeared to ridicule Arsenal's latest bid for Luis Suarez on Wednesday after the Gunners reportedly tabled an offer of just over 40 million pounds for the striker.
Liverpool's slim Premier League title hopes faded further on Saturday when Michail Antonio's late header earned West Ham United a deserved point with a 2-2 draw.
Arsenal forward Alexis Sanchez can show Liverpool why he would have made the perfect replacement for Luis Suarez when the Chilean travels to Anfield in the Premier League on Sunday.
A round-up of Sunday night's matches in the Premier League.
Brazilian forward Julio Baptista scored four goals as Arsenal thumped Liverpool 6-3 in their League Cup quarter-final.
The result also means Everton have clinched fourth place to qualify for the Champions League for the first time.
IMAGES from the Premier League match played between Liverpool and Luton at Anfield on Wednesday
Images from Saturday's action in the Premier League.
Xabi Alonso has signed a three-year contract until June 2028 and the 43-year-old replaces Carlo Ancelotti, who took charge of his last game on Saturday.
Arsenal and Liverpool played out a pulsating 1-1 draw while Fenerbahce came from behind for a 2-1 home win over Chelsea in Wednesday's Champions League quarter-final, first leg matches.
Paris St Germain's Champions League triumph marked the culmination of a profound transformation, from a club defined by star power to one shaped by structure, tactical clarity and collective belief.
Images from the English Premier League matches played across England on Wednesday.
Liverpool striker Daniel Sturridge was substituted with a thigh injury as the English Premier League club beat Bayern Munich 3-0 in a pre-season match in Germany on Tuesday.
A summary of Sunday's action in the English Premier League.
Images from the English Premier League matches played on Sunday
Twenty-year-old Conor Bradley scored his first goal for Liverpool and claimed two assists as Juergen Klopp's team moved five points clear at the top
Arsenal suffered another painful Premier League defeat as Swansea City capitalised on some glaring errors to win 3-1 on Tuesday, boosting their survival hopes and denting the visitors' top four chances.
Tottenham Hotspur climbed to third with a 3-1 win over Southampton while Chelsea hung on to fourth spot, above Arsenal on goal difference, despite a 2-1 defeat at Wolverhampton Wanderers.
Arsenal's Arteta wary of old foe Villa
Arsenal are on a roll having won their last 12 matches in all competitions, while Liverpool smarting from a defeat in the Champions League.
IMAGES from the English Premier League matches played on Wednesday.
Wenger dropped Rob Holding for the visit to Stoke, preferring Shkodran Mustafi alongside Nacho Monreal and Sead Kolasinac at the back.
Arsenal beat Tottenham Hotspur 2-1 in a London derby while Liverpool got back to winning ways with a 4-1 win over Portsmouth.
Liverpool opened up a seven-point gap at the top of the English Premier League with a 1-0 win at Brighton & Hove Albion on Saturday, while Arsenal's poor away form continued with a 1-0 defeat at West Ham United.
IMAGES from the Premier League matches played on Saturday.